補(bǔ)體因子h（complement factor h）是膀胱腫瘤抗原（bladder tumor antigen, bta）的具體成分，是由尿路上皮腫瘤細(xì)胞和巨噬細(xì)胞產(chǎn)生的，不是正常表皮細(xì)胞產(chǎn)生的。補(bǔ)體因子h的產(chǎn)生賦予體內(nèi)腫瘤細(xì)胞一種選擇性生長(zhǎng)優(yōu)勢(shì)，讓細(xì)胞逃逸宿主免疫系統(tǒng)監(jiān)視，幫助腫瘤細(xì)胞逃脫人體內(nèi)在調(diào)控避免凋亡 。當(dāng)尿液補(bǔ)體因子h水平較高時(shí)，提示尿路上皮腫瘤的發(fā)生。補(bǔ)體因子h可用于尿路上皮腫瘤的早期檢測(cè)和復(fù)發(fā)監(jiān)測(cè)。
生物功能：
補(bǔ)體因子h（傳統(tǒng)習(xí)慣簡(jiǎn)稱為bta）在控制補(bǔ)體激活替代途徑的時(shí)候扮演關(guān)鍵的負(fù)反饋?zhàn)饔?，這個(gè)替代補(bǔ)體途徑可以裂解外來細(xì)胞。bta結(jié)合補(bǔ)體因子c3b后，可以抑制膜攻擊復(fù)合物的形成，從而阻止細(xì)胞裂解。bta干擾補(bǔ)體級(jí)聯(lián)反應(yīng)，以免細(xì)胞被補(bǔ)體裂解。bta的產(chǎn)生賦予體內(nèi)腫瘤細(xì)胞一種選擇性生長(zhǎng)優(yōu)勢(shì)，讓細(xì)胞逃逸宿主免疫系統(tǒng)監(jiān)視 。
臨床應(yīng)用：
1檢測(cè)尿液補(bǔ)體因子h（bta）水平可對(duì)尿路上皮腫瘤進(jìn)行早期鑒別和復(fù)發(fā)監(jiān)測(cè)。
2聯(lián)合尿液補(bǔ)體因子h（bta）和尿細(xì)胞學(xué)檢查用于膀胱癌高危人群篩查。
艾美捷補(bǔ)體因子h抗體及相關(guān)熱門研究：
編號(hào)名稱規(guī)格
m099mouse c1q小鼠補(bǔ)體c1q蛋白
m113mouse c3小鼠補(bǔ)體c3蛋白
m114mouse c3b小鼠補(bǔ)體c3b蛋白
r099rat c1q大鼠補(bǔ)體c1q蛋白
r113rat c3大鼠補(bǔ)體c3蛋白
r114rat c3b大鼠補(bǔ)體c3b蛋白
r137rat factor h大鼠factor h補(bǔ)體因子
rb113rabbit c3兔補(bǔ)體c3蛋白
r237goat anti-rat factor h山羊抗大鼠因子h抗體1.0ml
b102gvb++ (with ca and mg)*250ml
b100gvb++ (with ca and mg)*1liter
b103gvb° (without ca and mg)*250ml
b101gvb° (without ca and mg)*1liter
b104gvbe (with edta)*250ml
b105gvbe (with edta)*1liter
b110sgvb++ (low ionic strength gvb++ w/ sucrose)*250ml
b111sgvb++ (low ionic strength gvb++ w/ sucrose)*1liter
b112vbs++ (with ca and mg)*250ml
b113vbs++ (with ca and mg)*1liter
b114vbso (without ca and mg)*250ml
b115vbso (without ca and mg)*1liter
b200ea (ab-sensitized sheep e)*5ml@5x108/ml
b201ea (ab-sensitized sheep e)*10ml@5x108/ml
b202ea (ab-sensitized sheep e)*20ml@5x108/ml
b210es (sheep e)*20ml@5x108/ml
b300er (rabbit e)*5ml@5x108/ml
b301er (rabbit e)*10ml@5x108/ml
b302er (rabbit e)*20ml@5x108/ml
b400zymosan10ml@1x109/ml
b106mgegta10ml@0.1m
b250mcar1.0ml
hemolysinhemolysin2.0ml